cyclover-amine

Using Cyclover, we have demonstrated successful synthesis of a short peptide[1]. Thanks to the pioneering work by Japanese scientists, Cyclover performs practically well as Jitsubo’s Molecular Hiving and Ajinomoto’s Ajiphase according to their published literature. Therefore, their papers are valuable references to develop Cyclover for peptide synthesis[2,3], for oligonucleotide synthesis[4] and for PMO synthesis by precipitation [5] and extraction [6].

CA Index Name of Cyclover-Amine:

N2,N2,N4,N4-tetraoctadecyl-6-(1-piperazinyl)-1,3,5-triazine-2,4-diamine

CAS Registry Number (CAS RN): [3018086-90-0]

References:

[1] Yongfu Li: Composition of a lipophilic agent for solution phase synthesis of biomolecules US2023/0373936A1 and WO2023/244274A2.

[2] Yohei Okada, Rico Takasawa, Daisuke Kubo, Natsumi Iwanaga, Shuji Fujita, Kosuke Suzuki, Hideaki Suzuki, Hidehiro Kamiya and Kazuhiro Chiba: Organic Process Research and Development 2019, 23, 2576-2581.

[3] Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim and Kazuhiro Chiba: Tetrahedron 2013, 69, 2555-2559.

[4] Shokaku Kim, Masanori Matsumoto and Kazuhiro Chiba: Chemistry: a European Journal 2013, 19, 8615-8620.

[5] Torii Takayoshi, Takahashi Daisuke and Katayama Satoshi: Morpholino oligonucleotide manufacturing method US10415036.

[6] Takahashi, Daisuke and Torii, Takayoshi: Morpholino oligonucleotide manufacturing method US11028386.