Li-Resin swells more homogeneously in solvents commonly used for solid phase synthesis and also excellently in aqueous medium. The swellability profile was determined using common solvents for solid phase synthesis. The results were collected into one graph in comparison with the data of polystyrene (PS) resin and polyethylene glycol (PEG) resin. Unlike the PS resin which is poorly solvated in acetonitrile, DMSO, methanol, trifluoroacetic acid, and water, and unlike the PEG resin which is extremely solvated in trifluoroacetic acid, Li-Resin is more homogeneous among the solvents tested. This is remarkably advantageous for solid phase synthesis because the resin bed of Li-Resin may not expand and shrink dramatically due to the solvent change during a synthesis cycle, providing a more stable and more consistent condition for solid phase synthesis and therefore better quality of the bio-molecule synthesized.