Struture of Cyclover:

Property of Cyclover and its derivatives:

Cyclophase synthesis:

One Cycle of Synthetic Process:

(1) Dissolve the reactants in solution by using one volume of DCM or THF.

(2) React to completion by checking TLC or other analytical methods.

(3) Precipitate for separation by mixing 4 to 5 fold volumes of methanol.

(4) Filter to collect the solid for next reaction.